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pentobarbital will minimize the level or result of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Pitolisant publicity is decreased by fifty% if coadministered with solid CYP3A4 inducers.pentobarbital boosts toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metaboli